Acly Rabbit Anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Recombinant Acly, Each

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Atp citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-coa in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-coa and oxaloacetate from citrate and coa with a concomitant hydrolysis of atp to adp and phosphate. The product, acetyl-coa, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, atp citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [Provided by refseqsequence: ttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpdqlikrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepf