Adenosine Analog, Viral Dna Polymerase Inhibitor, And Dna Chain Terminator Used To Treat Hepatitis B Infection. It Also Decreases Levels Of Treg Cells And Increases Levels Of Il-4, Il-2, Tnf-A, And Ifn-?, Each

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Adefovir dipivoxil is the diester form of adefovir, an antiviral prodrug that displays immunomodulatory activity. Adefovir is an acyclonucleotide analog that inhibits viral dna polymerase, acting as a dna chain terminator. Adefovir is primarily used to treat hepatitis b infection, but also displays activity against retroviruses. Adefovir decreases levels of treg cells and increases levels of il-4, il-2, tnf-a, and ifn-?. Additionally, this compound may show anti-arthritic activity as well, inhibiting production of no and expression of rantes and acting both as a prophylactic or a rescue treatment in animal models of adjuvant-induced arthritis.