Aiolos Mouse Anti-Mouse, Alexa Fluor 647, Clone: S48-791, Bd, Mouse Monoclonal Antibody, Each

Details:

The s48-791 monoclonal antibody specifically recognizes the transcription factor, aiolos, which is encoded by ikzf3 , ikaros family zinc finger 3. Aiolos belongs to the ikaros family of zinc-finger proteins that includes ikaros and helios. Aiolos can form homodimers or heterodimers with other ikaros family members. Aiolos is expressed in committed lymphoid progenitors, thymocytes, and mature types of t and b lymphocytes and nk cells. It is not expressed by hematopoietic stem cells. Aiolos plays an important role in the control of b lymphocyte differentiation and proliferation and is specifically required for the generation of long-lived, high affinity plasma cells in the bone marrow. Aiolos is involved in regulating bcl2 expression and controlling apoptosis in t-cells in an il2-dependent manner. Aiolos is also expressed by th17 cells and reportedly promotes their differentiation by downregulating il-2 expression.