Aip1 Mouse, Unlabeled, Clone: 49, Bd, Mouse Monoclonal Antibody, Each

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Apoptosis is a selective process of genetically programmed cell death which occurs during normal cell differentiation and development of multicellular organisms. In vertebrates, t cell and neuronal development are probably the best characterized systems for the study of apoptosis. Alg-2 and alg-3 (apoptosis-linked genes 2 and 3) were identified as low molecular weight ca2+ -binding proteins essential for apoptosis through the activation of the fas receptor in t cells. Alg-2 interacting protein 1 (aip1/alix) is a ubiquitous protein that associates with alg-2 in the cytosol in a ca2+; dependent manner. Aip1 is homologous to the yeast protein, bro1, which has been implicated in pkc1p- ap kinase signaling. A truncated form of aip1 protects against serum starvation-, etoposide-, and staurosporine-induced cell death. In addition, the c-terminal proline rich region of aip1 facilitates interaction with sh3 domain-containing protein expressed in tumorigenic astrocytes (seta) and this interaction may be important for mediating dna damage-dependent apoptosis in astrocytes. Thus, aip1 interacts with alg-2 or seta, or both, during activation of cell death pathways in a variety of cell types.Host species: mouseclone: 49isotype: igg1species reactivity [for features main]: ratimmunogen: mouse aip1 aa. 375-580Immunofluorescence, western blotting