Aire Rabbit Anti-Human, Mouse, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Peptide Of Aire, Each

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This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator cbp. At least three splice variant mrnas products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (nmd). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (apeced). [Provided by refseq