Annexin Vii Mouse Anti-Human, Unlabeled, Clone: 5, Bd, Mouse Monoclonal Antibody, Each

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Annexin vii, also known as synexin, is a member of the annexin family characterized by ca2+ dependent phospholipid binding. Annexins have a four-fold internal repeat of about 70 amino acids that contains the ca2+-binding sites. They also have a regulatory nh2-terminal region of 30-40 amino acids. Annexin vii mrna has been detected in many tissues and is most abundant in brain, heart, skeletal muscle, and lung. Annexin vii mrna exhibits a tissue dependent polymorphism due to alternative splicing which results in two different isoforms of 47kda and 51kda. In vitro, annexin vii aggregates chromaffin granules and enhances membrane fusion in a ca2+ and gtp-dependent manner. Although the physiological role of annexin vii is not completely understood, it is believed to influence and regulate ca2+ dependent events such as secretion at the plasma membrane.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting