Cd123 Mouse Anti-Human, Na/Le, Unlabeled, Clone: 7g3, Bd, Mouse Monoclonal Antibody, Each

Details:

Reacts with human cd123, the 70kda il-3 receptor α chain (il-3rα), which associates with the 120-140kda β subunit. The β chain is shared with the receptors for interleukins il-5 and gm-csf. Il-3rα is expressed on hematopoietic progenitors and plays an important role in hematopoietic progenitor cell growth and differentiation. This antibody has been reported to block the binding of 125i-il-3 to high and low affinity il-3 receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell-mediated il-8 secretion, and neutrophil transmigration. This antibody has been reported to be useful for immunoprecipitation, western blot and immunofluorescent staining for flow cytometry. At the fifth hlda workshop, the human il-3 receptor was designated cd123.