Apaf1 Rabbit Anti-Human, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Peptide Of Apaf1, Each

Details:

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the wd-40 domain, a caspase recruitment domain (card), and an atpase domain (nb-arc). Upon binding cytochrome c and datp, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [Provided by refseq