Apob Goat Anti-Human, Polyclonal Antibody, Abnova, Goat Polyclonal Antibody Raised Against Native Apob, Each

Details:

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apob-48 and apob-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apob are encoded by a single gene from a single, very long mrna. The two isoforms share a common n-terminal sequence. The shorter apob-48 protein is produced after rna editing of the apob-100 transcript at residue 2180 (caa->uaa), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apob, diseases affecting plasma cholesterol and apob levels. [Provided by refseq