Arginase I Mouse, Unlabeled, Clone: 19, Bd, Mouse Monoclonal Antibody, Each

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Arginase converts arginine into urea plus ornithine, the final step in urea synthesis. Two different isoforms (i&ii) have been isolated with approximately 60% homology at the nucleotide level. While type ii is present in many tissues, arginase i is expressed exclusively in liver. In cultured macrophages, as well as in vivo, arginase i is induced with nitric oxide synthase (nos) and the arginase i transactivator c/ebpβ in response to lipopolysaccharide. This response occurs in a dose and time-dependent manner. While the mrna for nos appears as early as 2h after treatment, mrna levels for arginase i peak after twelve hours of lipopolysaccharide treatment. Since the synthesis of nitric oxide by nos requires arginine, the delayed induction of arginase i may be necessary for the regulation of nos activity.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting