Eta;-Arrestin Mouse, Unlabeled, Clone: 10, Bd, Mouse Monoclonal Antibody, Each

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Eta;-arrestins were discovered due to their ability to modulate interactions between the phosphorylated β2-adrenergic receptors and g proteins. This modulation results in diminished β2-adrenergic receptor function, also known as desensitization. Because arrestins are found at the synaptic terminals, they may provide a termination mechanism that allows the neurons to regain their original polarization and respond to a new neurotransmitter stimulus. The c-terminal region of arrestins is involved in selecting the phosphorylated and activated adrenergic receptors. The β-arrestin1 gene encodes a protein of 418 amino acids with an approximate molecular weight of 55kda. Β-arrestin1 protein is highly homologous to the 45kda β-arrestin2. Both proteins are widely expressed, but are especially abundant in the central nervous system.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting