Baf47 Mouse, Unlabeled, Clone: 25, Bd, Mouse Monoclonal Antibody, Each

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Swi/snf complexes facilitate gene activation and transcription factor binding by altering repressive chromatin structures in an atp-dependent manner. In mammals, swi/snf complexes are present in mutliple forms that include 9-12 brg1-associated factors (bafs) per complex. These baf proteins range in molecular weight from 47 to 250kda. Baf47/snf5 (smarcb1/ini1) complexes with brg1- and brm-containing swi/snf complexes. Baf47/snf5 mrna is widely expressed in cell lines and tissues, and baf47/snf5 gene is mutated in many human tumors. The latter is indicative of a tumor suppressor role for baf47/snf5. In addition, mice deficient for baf47 die early in embryogenesis, while baf47/snf5 heterozygous mice display a variety of tumors in the soft tissues of the head and neck. Baf47/snf5 also binds the hiv-1 integrase and stimulates integrase-mediated dna joining activity. Thus, baf47/snf5 is a component of swi/snf complexes that may be critical for normal development and tumor suppression, but may also be a protein utilized for viral dna integration into host dna.Western blotting