Bag3, Rabbit, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Partial Recombinant Bag3, Each

Details:

Bag proteins compete with hip for binding to the hsc70/hsp70 atpase domain and promote substrate release. All the bag proteins have an approximately 45-amino acid bag domain near the c terminus but differ markedly in their n-terminal regions. The protein encoded by this gene contains a ww domain in the n-terminal region and a bag domain in the c-terminal region. The bag domains of bag1, bag2, and bag3 interact specifically with the hsc70 atpase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the atpase domain of hsc70 and inhibit its chaperone activity in a hip-repressible manner. [Provided by refseq