Bcl-X Mouse, Unlabeled, Clone: 44, Bd, Mouse Monoclonal Antibody, Each

Details:

Bcl-x is related to the bcl-2 protein and can function independently of bcl-2 in regulating apoptosis (programmed cell death). The bcl-x transcript is expressed in a number of tissues, with the highest levels in the lymphoid and central nervous systems. Two distinct cdna species, bcl-xl and bcl-xs, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of the bcl-x gene. Bcl-xl is composed of 233 amino acids and is similar in size and structure to bcl-2. The bcl-xs polypeptide shows a deletion of 63 amino acids which consist of the region of bcl-xl with the highest degree of amino acid identity to bcl-2. Like bcl-2, bcl-xl inhibits cell death upon growth factor withdrawal when transfected into an il-3-dependent cell line. However, bcl-xs inhibits bcl-2 mediated cell survival.