Biomagplus Concanavalin A, Each

Details:

Concanavalin a (con a) is covalently attached to functionalized biomagplusparticles for use in glycoprotein isolations from serum and cellular extracts.Con a is a 104,000 da protein comprised of four identical subunits, and existsas an active dimer or tetramer depending upon ph. Its carbohydrate bindingpartners are α-d-glucose and α-d-mannose with unmodified oh groups atc-3, c-4, and c-6, and terminal glucose residues of proteins and peptides.Con a agglutinates red blood cells (rbcs), interacts with immunoglobulinglycopeptides, and is a lymphocyte mitogen. It binds some bacteria.Con a binding is mediated by metal ions, which stabilize is conformation. Eachbinding site requires calcium and manganese ions, and use of buffers with edtaor other metal chelators will result in a loss of carbohydrate binding ability