C-Cbl Mouse, Unlabeled, Clone: 17, Bd, Mouse Monoclonal Antibody, Each

Details:

Cbl was identified in the genome of a transforming retrovirus from a mouse pre-b cell lymphoma. The product of mammalian c-cbl, p120[cbl], is a widely expressed cytoplasmic protein with several distinctive domains including a ring finger motif and a large proline-rich domain. Although the normal cellular function of c-cbl has not yet been determined, it associates with many well known signal transduction proteins. In lymphoid cells, c-cbl is a substrate of tcr-activated protein tyrosine kinases. In addition, stimulation with egf, pdgf, fgf, or ngf results in tyrosine-phosphorylation of c-cbl in lymphoid and other cell types. It forms a signaling complex with grb2 in t cells and is a sh3 and sh2 binding protein which associates with many other cytoplasmic signaling proteins including btk, src, fyn, lck, and the β isoform of pi-3 kinase. Thus, c-cbl may be an important adaptor protein in growth factor and t-cell receptor signaling pathways.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting