Calcineurin Mouse, Unlabeled, Clone: 29, Bd, Mouse Monoclonal Antibody, Each

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Calcineurin is a ca2+/calmodulin-dependent protein phosphatase. The active enzyme is a heterodimer of a large calmodulin-binding catalytic subunit a (61kda) and a smaller ca2+ binding subunit b (19kda). Regions corresponding to the calmodulin-binding site, an autoinhibitory domain, and a putative subunit b binding site have been identified within the large subunit a. The activity of calcineurin is sensitive to immunosuppressants such as cyclosporin a (csa) and tacrolimus (fk506). The study of fk506-mediated inhibition of nitric oxide formation has revealed that nitric oxide synthase (nos) is a calcineurin substrate. Calcineurin dephosphorylates nos and enhances its catalytic activity. Therefore, calcineurin is an essential mediator for efficient t cell antigen receptor (tcr)-mediated t cell activation.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting