Cam Kinase Ii Mouse, Unlabeled, Clone: 45, Bd, Mouse Monoclonal Antibody, Each

Details:

Ca2+;/calmodulin-dependent protein kinase ii (cam kinase ii) is a multifunctional ser/thr kinase that regulates a number of cellular functions in response to increased intracellular ca2+;. Cam kinase ii is widely distributed, but is predominantly expressed in brain. It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning. Neuronal cam kinase ii contains heteromers of two major subunits, α and β, at a ratio of 2:1 and homomers of α subunits. Each subunit has n-terminal atp-binding and catalytic/regulatory domains and a c-terminal association domain. The regulatory domain consists of the autoinhibitory and calmodulin-binding sites. Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation. After binding ca2+;/calmodulin, cam kinase ii undergoes rapid autophosphorylation of the α and β subunits, which results in a substantial increase in its affinity for ca2+;/calmodulin.Host species: mouseclone: 45isotype: igg1species reactivity: ratimmunogen: rat cam kinase iiα aa. 448-460Formula weight [chemical]: 52kdaimmunofluorescence, immunohistochemistry, western blotting