Caspase-2 Mouse Anti-Human, Unlabeled, Clone: 35, Bd, Mouse Monoclonal Antibody, Each

Details:

Caspase-2/ich-1 is related to the c. Elegans cell death gene product ced-3 and its mammalian homologue interleukin-1β-converting enzyme (ice). Caspase-2 /ich-1 was identified from a mouse cdna library and originally termed nedd-2. The nedd-2 mrna was found to be expressed during early mouse embryonic brain development and subsequently down-regulated in adult neuronal tissue. With the identification of the human nedd-2 gene, the murine gene was renamed ich-1 to symbolize ice and ced-3 homology. Caspase-2/ich-1 mrna is alternatively spliced. The larger mrna species encoding a product of 435 amino acids is known as caspase-2 long, or ich-1l. The smaller mrna species encoding a protein of 312 amino acids is named caspase-2 short, or ich-1s. Overexpression of ich-1l induces apoptosis, while over-expression of ich-1s suppresses rat-1 cell death induced by serum deprivation. Thus, it appears that caspase-2/ich-1 plays an important dual role in programmed cell death.Immunofluorescence, western blotting