Eta;-Catenin Mouse, Unlabeled, Clone: 14, Bd, Mouse Monoclonal Antibody, Each

Details:

Eta;-catenin is a 92kda protein that binds to the cytoplasmic tail of e-cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of e-cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for e-cadherin function. Although the α- and β-catenins have been cloned, very little is known about their biochemical roles. However a link between β-catenin and colon cancer has been described. Β-catenin was found to co-immunoprecipitate with the apc tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-cadherin, however, was not detectable in these complexes. Thus the apc-catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting