Gamma;-Catenin Mouse, Unlabeled, Clone: 15, Bd, Mouse Monoclonal Antibody, Each

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Gamma;-catenin (plakoglobin) was identified as a compenent of desmosomes where it associates with desmoglein. Γ-catenin and β-catenin are closely related proteins that have significant homology with the drosophila armadillo protein. In addition to complexing with e-cadherin, γ-catenin and β-catenin have been observed in association with the intracellular domain of n-cadherin. It has been proposed that one molecule of α-catenin and at least one molecule of β-catenin and γ-catenin simultaneously bind to a single cadherin molecule. A 19 amino acid sequence of desmoglein (dsg1) was found to be critical for binding of γ-catenin. This region has significant homology to the catenin-binding domain of classical cadherins, thus suggesting a common mechanism for γ-catenin localization at both adherens junctions and desmosomes.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting