Delta;-Catenin Mouse, Unlabeled, Clone: 30, Bd, Mouse Monoclonal Antibody, Each

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The catenins (α, β, γ, δ, p120[ctn]) are cytoplasmic proteins that are related to the drosophila armadillo protein. Catenins may have dual roles since they are components of cell-cell adherens junctions and can translocate to the nucleus after stimulation of the wingless (wnt-1 homolog) signaling pathway. Α-catenin has two subtypes: αe-catenin, which is expressed ubiquitously, and αn-catenin, which is expressed in the nervous system. Β-catenin binds to the cytoplasmic tail of e-cadherin at adherens junctions and has been implicated in wnt-1 signaling. Γ-catenin is associated with desmoglein in desmosomes and is closely related to β-catenin. P120[ctn] is related to both β- and γ-catenin and is a substrate of tyrosine kinases localized at adherens junctions. Δ-catenin was identified by its ability to bind the alzheimer's disease-related protein, presenilin-1. It is most closely related to p120[ctn] and the desmosomal protein, p0071. It contains 10 armadillo (arm) repeats, as compared to the 13 arm repeats found in β-catenin. Δ-catenin is expressed at high levels in the developing nervous system, where it may be involved in neuronal progenitor cell migration and dendrite development.Host species: mouseclone: 30isotype: igg1species reactivity: ratimmunogen: mouse δ-catenin aa. 85-194Formula weight [chemical]: 160kdaimmunofluorescence, western blotting