Caveolin 2 Mouse, Unlabeled, Clone: 65, Bd, Mouse Monoclonal Antibody, Each

Details:

Identified as a tyrosine phosphorylated protein in rous sarcoma virus- transformed chick embryo fibroblasts (cef), caveolin is now known to be ubiquitously expressed. Caveolin (also known as vip21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-golgi network (tgn) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (gpi)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize gpi-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, annexin ii, and hetero-trimeric g proteins. Although caveolin 2 is similar to caveolin 1 in distribution and tissue expression, caveolin 2 is most abundant in adipose tissue and its expression is up-regulated upon differentiation. This antibody has been reported to recognize an epitope located within region 79-88 of caveolin 2.