Cd115 Rat Anti-Human, Alexa Fluor 647, Clone: 9-4d2-1e4, Bd, Rat Monoclonal Antibody, Each

Details:

The 9-4d2-1e4 monoclonal antibody specifically binds to cd115 which is also known as colony stimulating factor 1 receptor (csf-1r) or macrophage colony-stimulating factor 1 receptor (m-csfr). This type i transmembrane glycoprotein is a receptor tyrosine kinase (rtk) that belongs to the ig superfamily. It is expressed on a variety of cells including those committed to the mononuclear phagocyte lineage, such as, monocytes, macrophages, and osteoclasts. Csf-1 binds to and signals through csf-1r homodimers which undergo tyrosine autophosphorylation and transduce downstream signaling pathways resulting in cytoskeletal reorganization and gene expression. Csf-1r activation stimulates the proliferation, differentiation, and survival of cells within the mononuclear phagocyte system. Acting through cd115, csf-1 induces macrophage spreading and motility, and in combination with rankl, csf-1 drives the differentiation of mononuclear phagocytes to become osteoclasts. Interleukin-34 (il-34) is another ligand for cd115 that can induce similar, as well as, some different biological responses by cd115-positive target cells.