Cd117 Mouse Anti-Human, Brilliant Violet 421, Clone: Yb5.B8, Bd, Mouse Monoclonal Antibody, Each

Details:

The yb5.B8 monoclonal antibody specifically binds to cd117. Cd117, also known as c-kit, is a 145 kda cell-surface glycoprotein with tyrosine kinase activity. Cd117 is present on hematopoietic progenitor cell subsets, thymocytes, mast cells, hepatocytes and histiocytes.Cd117 serves as a cytokine receptor for steel factor (slf), also known as stem cell factor (scf) or mast cell growth factor (mgf). The interaction of c-kit and slf is crucial to hematopoiesis, mast cell differentiation, melanogenesis, and germ cell development. The ability ofthe yb5.B8 antibody to block the binding of c-kit ligand is still controversial. The antibody was conjugated to brilliant violet 421 and has been developed in collaboration with sirigen. With an ex max of 407-nm and em max at 421-nm, brilliant violet 421 can be excited by the violet laser and detected in the standard pacific blue filter set (eg, 450/50-nm filter). Brilliant violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to pacific blue conjugates.Host species: mouseclone: yb5.B8isotype: igg1, κspecies reactivity: humanflow cytometry