Cd11a Rat Anti-Mouse, Fitc, Clone: 2d7, Bd, Rat Monoclonal Antibody, Each

Details:

The 2d7 monoclonal antibody specifically binds to the 180-kda α; l chain of lfa-1 (cd11a/cd18, α; l β; 2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes. Cd8a+cd8b- intestinal intraepithelial t lymphocytes, which are believed to be thymus independent, do not express cd11a. Lfa-1 mediates a variety of heterotypic and homotypic intracellular adhesions through interaction with icam-1 (cd54) and icam-2 (cd102), including participation in the immunological synapses between cd8+ t lymphocytes and antigen-presenting cells. Mab 2d7 has been reported to block an in vitro allogeneic mixed-leukocyte reaction. The 2d7 and m17/4 (cat. No. 553337, For the na/le™ format) antibodies are reported to recognize different epitopes of the cd11a molecule.