Cd11b/Mac-1 Mouse Anti-Human, Buv395, Clone: Icrf44 (Also Known As 44), Bd, Mouse Monoclonal Antibody, Each

Details:

The icrf44 monoclonal antibody specifically binds to cd11b, the 165-kda adhesion glycoprotein that associates with the 95-kda integrin β 2 (cd18) to form the cd11b/cd18 complex, also known as mac-1 or cr3. Cd11b is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of nk cells. Cd11b functions in cell-cell and cell-substrate interactions and is a receptor for ic3b, cd54 (icam-1), cd102 (icam-2) and cd50 (icam-3). This antibody significantly inhibits polymorphonuclear leukocyte aggregation in response to fmlp. The antibody was conjugated to bd horizon™ buv395 which has been exclusively developed by bd biosciences as an optimal dye for use on a 355nm laser equipped instrument. With an ex max at 348nm and an em max at 395nm, this dye has virtually no spillover into any other detector. Bd horizon™ buv395 can be excited with a 355nm laser and detected with a 379/28 filter.