Cd11b Rat Anti-Mouse, V450, Clone: M1/70, Bd, Rat Monoclonal Antibody, Each

Details:

The m1/70 antibody reacts with the 170kda α(m) chain of mac-1 (cd11b/cd18, α(m)β(2) integrin), also known as complement receptor 3 (cr3), which mediates adhesion to c3bi and icam-1 (cd54). Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and b-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that cd62l (l-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence and c3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mab m1/70 with cd11b on human monocytes, polymorphonuclear leukocytes, and nk cells has been reported.Host species: ratclone: m1/70isotype: igg2b, κspecies reactivity: mouseimmunogen: mouse splenic cellsflow cytometry