Cd122 Rat Anti-Mouse, Apc, Clone: Tm-Beta 1, Bd, Rat Monoclonal Antibody, Each

Details:

The tm- β 1 antibody reacts with the 90-100-kda β chain shared by the il-2 and il-15 receptors (il-2r β , cd122). In the periphery, cd122 is expressed on cd8 t lymphocytes, nk cells, nk-t cells, dendritic epidermal t cells, subsets of intraepithelial lymphocytes, and macrophages. Small subsets of fetal and adult thymocytes constitutively express cd122. Cd122 cells in the bone marrow include committed nk-cell progenitors. Il-2r β expression is upregulated by il-2. Cd122 is a transmembrane glycoprotein of the hematopoietin receptor superfamily which can combine with cd132 ( γc) alone or cd132 plus cd25 (il-2r α ) to form intermediate or high-affinity il-2 receptor complexes, respectively. The β chain of these complexes, cd122, is involved in signal transduction and immunoregulation. The tm- β 1 antibody blocks high affinity binding of il-2 or il-15 to il-2r β .