Cd127 Mouse Anti-Human, Apc-R700, Clone: Hil-7r-M21, Bd, Mouse Monoclonal Antibody, Each

Details:

The hil-7r-m21 monoclonal antibody specifically binds to the 60-90 kda glycoprotein, cd127. Cd127 is also known as the il-7 receptor alpha (il-7r α ) subunit. The il-7 receptor complex is a heterodimer composed of cd127 and the common gamma chain ( γc, cd132), shared by other cytokine receptors (il-2r, il-4r, il-9r, il-15r, and il-21r). Cd127 is expressed on thymocytes, t- and b-cell progenitors, mature t cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of cd127 is down-regulated following t cell activation. Studies indicate that the il-7 receptor plays an important role in the proliferation and differentiation of mature t cells. Recently, it has been shown that low surface expression of cd127, in combination with intermediate to high surface expression of cd25, the α chain of the il-2 receptor complex, can distinguish between human regulatory and conventional cd4 t cells in human adult and cord blood, lymph nodes and thymus.