Cd16 Mouse Anti-Human, Non-Human Primate, Alexa Fluor 488, Clone: 3g8, Mouse Monoclonal Antibody, Each

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Cd16 (fcgr3a) is a 50-65 kda cell surface molecule that exists in two forms - a transmembranous form expressed by nk cells and some t cells, and a phosphatidylinositol linked form expressed by granulocytes. Cd16 is a low affinity receptor for igg (fcr iii), and is an important receptor mediating adcc by nk cells. Human cd16 is expressed in two forms – fcgr3a and fcgr3b. Fcgr3a is associated with the fcepsilonri-gamma subunit and is responsible for antibody-dependent nk cell cytotoxicity. Mast cell fcgr3a is associated, with fcepsilonri-beta subunit. Besides igg, fcgr3a can be triggered also by oligomeric ige. Fcgr3b is a gpi-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseases associated with cd16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.