Cd178 Mouse Anti-Human, Unlabeled, Clone: Nok-2, Bd, Mouse Monoclonal Antibody, Each

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Fas (apo-1, cd95) is a 45kda cell surface protein that mediates apoptosis when cross-linked with agonistic anti-fas antibodies or fas ligand (fasl). Fas belongs to the tnf (tumor necrosis factor)/ngf (nerve growth factor) receptor family, and is expressed in various tissue and cells including the thymus, liver, ovary, and lung. Fasl is a 40kda tnf family membrane protein that induces apoptosis by binding to fas, its cell-surface receptor. Fasl is expressed on activated t and nk cells. Both fas and fasl are thought to play an important role in the apoptotic processes that take place during t cell development. Nok-2 recognizes human fasl. It recognizes both the membrane bound (fasl) and soluble (sfasl) forms. L5178y mouse t lymphoma cells expressing recombinant human fasl were used as immunogen. Fasl and sfasl migrate at reduced molecular weights of 40 and 26kda, respectively. However, the molecular weights observed in a particular sample may vary according to fasl and sfasl glycosylation and breakdown patterns as described in tanaka et al.