Cd18 Rat Anti-Mouse, Na/Le, Unlabeled, Clone: Game-46, Bd, Rat Monoclonal Antibody, Each

Details:

The game-46 antibody reacts with the common β2 chain of lfa-1 (cd11a/cd18, αlβ2 integrin), mac-1 (cd11b/cd18, αmβ2 integrin), and gp150, 95 (cd11c/cd18, αxβ2 integrin). Expression of cd18 is limited to leukocytes, where it is widely distributed in consort with each of the three integrin α chains (cd11a, cd11b, and cd11c). Among splenocytes, nk cells have the highest density of cd18, and t lymphocytes express a higher density than the remaining cells. The β2 integrins are important mediators of leukocyte-endothelium interactions. It has been reported that game-46 antibody blocks in vitro adhesion of lfa-1-expressing cells to the ligands icam-1, icam-2 and icam-3 and of mac-1-expressing cells to icam-1, c3bi, and fibrinogen.