Cd183 Mouse Anti-Human, Apc, Clone: 1c6/Cxcr3, Bd, Mouse Monoclonal Antibody, Each

Details:

The 1c6/cxcr3 monoclonal antibody specifically binds to human cd183, also known as the cxcr3 chemokine receptor. Cd183 is a 40-41 kda seven-transmembrane protein and member of the g protein-coupled receptor family. Cd183 is expressed primarily on activated t cells that infiltrate inflammatory sites. It has also been detected on some circulating t cells, b cells, and nk cells. Reports show that some cxcr3-positive t cells also express ccr5 and are mostly cd45ro-positive cells. Three ligands for cxcr3 have been identified. They are cxcl9 (mig/monokine induced b y interferon-γ), cxcl10 (ip-10/interferon-γinducible 10- kd protein), and cxcl11 (i-tac/interferon-inducible t-cell alpha chemoattractant). These chemokines are produced by a variety of cells upon stimulation by ifn-γand interact with cxcr3 to medi ate t-cell chemotaxis. This reagent has been reported to be suitable for immunohistochemical staining of acetone-fixed, frozen sections and/or formalin-fixed, paraffin-embedded tissue sections with citrate pretreatment. Clone 1c6/cxcr3 also cross reacts with a subset of peripheral blood lymphocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The distribution of lymphocytes is similar to that observed with cd183-positive peripheral blood lymphocytes from normal human donors. Cxcr3 has been clustered as cd183 in the viith hlda workshop.