Cd19 Mouse Anti-Human, Brilliant Violet 421, Clone: Hib19, Bd, Mouse Monoclonal Antibody, Each

Details:

The hib19 monoclonal antibody specifically binds to the 95 kda type i transmembrane cd19 glycoprotein. Cd19 is expressed during all stages of b-cell maturation and differentiation, except on plasma cells. Cd19 is also present on follicular dendritic cells. It is not found on t cells or on normal granulocytes. Cd19 is a signal transduction molecule that regulates b cell development, activation, proliferation and differentiation. It associates with the complement receptor 2 (cd21), tapa-1 (cd81), leu 13, and/or mhc class ii to form a signal transduction complex on the surface of b cells. Anti-cd19 clone hib19 partially blocks the binding of clone b43, another cd19-specific monoclonal antibody. The antibody was conjugated to brilliant violet 421 and has been developed in collaboration with sirigen. With an ex max of 407-nm and em max at 421-nm, brilliant vioet 421 can be excited by the violet laser and detected in the standard pacific blue filter set (eg, 450/50-nm filter). Brilliant violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to pacific blue conjugates.Host species: mouseclone: hib19isotype: igg1, κspecies reactivity: humanflow cytometry