Cd19 Mouse Anti-Human, Pe-Cf594, Clone: Hib19, Bd, Mouse Monoclonal Antibody, Each

Details:

The hib19 monoclonal antibody specifically binds to the 95 kda type i transmembrane cd19 glycoprotein. Cd19 is expressed during all stages of b-cell maturation and differentiation, except on plasma cells. Cd19 is also present on follicular dendritic cells. It is not found on t cells or on normal granulocytes. Cd19 is a signal transduction molecule that regulates b cell development, activation, proliferation and differentiation. It associates with the complement receptor 2 (cd21), tapa-1 (cd81), leu 13, and/or mhc class ii to form a signal transduction complex on the surface of b cells. Anti-cd19 clone hib19 partially blocks the binding of clone b43, another cd19-specific monoclonal antibody. This antibody is conjugated to bd horizon™ pe-cf594, which has been developed exclusively by bd biosciences as a better alternative to pe-texas red. Pe-cf594 excites and emits at similar wavelengths to pe-texas red yet exhibits improved brightness and spectral characteristics. Due to pe having maximal absorption peaks at 496nm and 564nm, pe-cf594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as pe-texas red (eg 610/20-nm filter).