Cd197 (Ccr7) Mouse Anti-Human, V450, Clone: 150503, Bd, Mouse Monoclonal Antibody, Each

Details:

The monoclonal antibody 150503 specifically binds to the human cc chemokine receptor, ccr7, also known as cd197. Ccr7 (previously known as blr2, ebi1 and cmkbr7), a seven-transmembrane, g-protein-coupled receptor, is the specific receptor for cc chemokines, mip-3β/exodus 3/elc/ ccl19 and 6ckine/exodus 2/slc/tca4/ccl21. Ccr7 mrna is expressed mainly in lymphoid tissues including spleen, lymph nodes and tonsil. Ccr7 is expressed on peripheral t and b lymphocytes, by bone marrow and cord blood cd34-positive cells and by mature dendritic cells. Differential ccr7 expression can be used to distinguish naive, central memory and effector memory t cell subsets. The human ccr7 gene, unlike other cc chemokine receptor genes, has been mapped to chromosome 17 (region 17q12).