Cd209a Rat Anti-Mouse, Apc, Clone: 5h10, Bd, Rat Monoclonal Antibody, Each

Details:

The 5h10 monoclonal antibody specifically binds to mouse cd209a, or cire, which is the most closely related homolog of human dc-sign. In the mouse, several homologs of human cd209 (dc-sign) have been described. Cd209a is a 238-amino acid type-ii transmembrane c-type lectin, with an extracellular carbohydrate recognition domain. It can bind to mannosylated ligands in a ca dependent manner. Cd209a is expressed by some conventional cd4 and cd4-cd8- dendritic cells (dc) but not by cd8 dc. It is also expressed on monocytes, splenic plasmacytoid pre-dc, macrophages, and resident peritoneal cells. Cd209a expression is downregulated upon cellular activation. Cd209a is thought to play a role in the internalization and presentation of antigens to initiate immune responses.