Cd210a Rat Anti-Human, Alexa Fluor 647, Clone: 3f9, Bd, Rat Monoclonal Antibody, Each

Details:

The 3f9 monoclonal antibody specifically binds to cd210a, which is also known as, interleukin-10 receptor subunit alpha (il-10r subunit alpha/il-10r α /il10ra), or interleukin-10 receptor subunit 1 (il-10r1). Cd210a is a 90-110 kda type i transmembrane glycoprotein that belongs to the type ii cytokine receptor family. Cd210a combines with il-10 receptor subunit beta (il-10r β /il10rb/cdw210b) to form the il-10 receptor complex ( il-10rα/il-10rβ ) that can bind il-10 and transduce signals intracellularly through the jak/stat pathway. Il-10 can suppress antigen presentation and the expression of proinflammatory type-1 immune responses while promoting type-2 immune responses. Cd210a is expressed on t cells, b cells, nk cells, monocyte, macrophages and dendritic cells. Clone 3f9 is specific for human cd210a and its binding to the receptor can be blocked by recombinant human il-10 (rhil-10) protein.