Cd222 Mouse Anti-Human, Alexa Fluor 647, Clone: Mem-238, Bd, Mouse Monoclonal Antibody, Each

Details:

The mem-238 monoclonal antibody specifically binds to cd222, which is also known as the insulin-like growth factor 2 receptor (igf2r, igf-ii receptor), cation-independent mannose 6-phosphate receptor (cimpr), or mannose-6 phosphate receptor (m6pr). Cd222 is ubiquitously expressed by a variety of cell types as a cell surface type i transmembrane glycoprotein. However, in the course of receptor trafficking between the cell surface and intracellular compartments, the majority of cd222 is found within cells. Cell surface cd222 functions as a multifunctional receptor that binds to a large number of extracellular ligands including acid hydrolases, insulin-like growth factors, latent tgf- β, leukemia inhibitory factor (lif), proliferin, prorenin, plasminogen, and herpes simplex vir us. It regulates extracellular insulin-like growth factor ii (igf-ii/igf-2) levels by binding and internalizing the growth factor for lysosomal degradation. This effectively removes igf-ii from the circulation and tissues and thus prevents it from signaling through the growth-stimulatory insulin-like growth factor i receptor (igf-1r, cd221) pathway. However, studies have reported that igf-ii may activate some cellular functions through cd222 as well. A soluble form of the cd222 extracellular region can also be detected in human serum and may play a role in regulating igf-ii activity. Cd222 serves as a surface receptor for latent tgfβ and can complex with plasminogen and cd87, a urokinase-type plasminogen activator receptor, to activate latent tgf- β. Cd222 also binds to a variety of mannose 6-phosphate (m6p)-containing proteins, including extracellular and newly-synthesized lysosomal enzymes, and transports them to lysosomes.