Cd226 Mouse Anti-Human, Alexa Fluor 647, Clone: Dx11, Bd, Mouse Monoclonal Antibody, Each

Details:

The dx11 monoclonal antibody specifically binds to cd226 which is also known as dnax accessory molecule-1 (dnam-1), platelet and t cell activation antigen 1 (pta1), or t lineage-specific activation antigen 1 antigen (tlisa1). Cd226 is a 65 kda type 1 transmembrane glycoprotein consisting of 318 amino acid residues including two ig-like domains. Cd226 is expressed on the majority of t cells, nk cells, monocytes, platelets, and a subset of b cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface cd3. Cd226 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. Cd226 is a tyrosine phosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic t lymphocyte (ctl)- or nk cell-mediated cytotoxicity. The dx11 antibody inhibits t- and nk cell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific t cells.