Cd226 Mouse Anti-Human, Na/Le, Unlabeled, Clone: Dx11, Bd, Mouse Monoclonal Antibody, Each

Details:

Reacts with dnax accessory molecule-1 (dnam-1), a 65kda transmembrane glycoprotein consisting of 318 amino acid residues including two ig-like domains. Dnam-1 is expressed on the majority of t cells, nk cells, monocytes, and a subset of b cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface cd3. Dnam-1 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. Dnam-1 is a tyrosinephosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic t lymphocyte (ctl)-mediated cytotoxicity. Dx11 inhibits t- and nkcell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific t cells.Flow cytometry