Cd244 Mouse Anti-Human, Brilliant Violet 421, Clone: 2-69, Bd, Mouse Monoclonal Antibody, Each

Details:

The 2-69 monoclonal antibody specifically binds to 2b4 which is also known as cd244. Cd244 is an approximately 63-70 kda type i transmembrane glycoprotein. It is a slam submember (slamf4) and cd2 family member of the immunoglobulin superfamily. Cd244 was originally identified in the mouse as a non-mhc-restricted cytotoxicity mediator present on nk cells and cd8 t cells. In humans, cd244 is expressed on nk cells, γδ t cells, subsets of effector and memory cd8 t cells, monocytes, eosinophils and basophils. This expression pattern suggests a broad role for cd244 in the regulation of leukocyte activation. Cd244 binds cd48 with high affinity. Cd244 may serve both stimulatory and inhibitory functions depending on a number of factors. These include the intensity and duration of cd244 interactions with its ligands as well as the presence of other signals generated through different receptor-ligand interactions. 2B4 was clustered as cd244 in the viith hlda workshop. The antibody was conjugated to bd horizon bv421 which is part of the bd horizon brilliant™ violet family of dyes. With an ex max of 407-nm and em max at 421-nm, bd horizon bv421 can be excited by the violet laser and detected in the standard pacific blue™ filter set (eg, 450/50-nm filter). Bd horizon bv421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to pacific blue conjugates.