Cd272 (Btla) Mouse Anti-Human, Apc, Clone:  J168-540, Bd, Mouse Monoclonal Antibody, Each

Details:

The j168-540 monoclonal antibody specifically binds to human cd272, also known as btla (b and t lymphocyte attenuator), an inhibitory receptor expressed in bone marrow and thymus on developing b and t cells. In the periphery, btla is expressed by b cells, t cells, bone marrow-derived dendritic cells, and macrophages. After t cell activation, btla appears to be expressed at higher levels on th1 cell populations than in th2 cell populations. Upon binding the herpesvirus entry mediator (hvem/light-r/cd270), cd272 undergoes tyrosine phosphorylation and inhibits t cell proliferation in a btla-dependent manner. Cd272 has structural similarities to two other lymphocyte inhibitory receptors, ctla-4 and pd-1 and is a member of the cd28-like family of coreceptors. Based on these observations, cd272 is considered to be a negative regulator of lymphocyte activation and/or function.