Cd272 (Btla) Mouse Anti-Human, Brilliant Violet 421, Clone:  J168-540, Bd, Mouse Monoclonal Antibody, Each

Details:

The j168-540 monoclonal antibody specifically binds to human cd272, also known as btla (b and t lymphocyte attenuator), an inhibitory receptor expressed in bone marrow and thymus on developing b and t cells. In the periphery, btla is expressed by b cells, t cells, bone marrow-derived dendritic cells, and macrophages. After t cell activation, btla appears to be expressed at higher levels on th1 cell populations than in th2 cell populations. Upon binding the herpesvirus entry mediator (hvem/light-r/cd270), cd272 undergoes tyrosine phosphorylation and inhibits t cell proliferation in a btla-dependent manner. Cd272 has structural similarities to two other lymphocyte inhibitory receptors, ctla-4 and pd-1 and is a member of the cd28-like family of coreceptors. Based on these observations, cd272 is considered to be a negative regulator of lymphocyte activation and/or function. The antibody was conjugated to bd horizon bv421 which is part of the bd horizon brilliant™ violet family of dyes. With an ex max of 407-nm and em max at 421-nm, bd horizon bv421 can be excited by the violet laser and detected in the standard pacific blue™ filter set (eg, 450/50-nm filter). Bd horizon bv421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to pacific blue conjugates.