Cd279 Mouse Anti-Human, Pe-Cf594, Clone: Eh12.1, Bd, Mouse Monoclonal Antibody, Each

Details:

The eh12.1 Monoclonal antibody specifically binds to cd279. Cd279 is an immunoregulatory receptor that is expressed on activated t cells, b cells and myeloid cells and contains an immunoreceptor tyrosine-based inhibitory motif (itim) in the cytoplasmic region. Mice deficient in cd279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. Pd-l1 and pd-l2 are ligands of cd279 and are members of the b7 gene family. Interaction of cd279:pd-ligands results in inhibition of t cell proliferation and cytokine secretion. Reports suggest that the b7/ctla-4 pathway functions primarily to attenuate, limit, and/or terminate naοve t-cell activation in secondary lymphoid organs. The pd-ligand:cd279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate t-, b-, and myeloid cell activation/effector function at sites of inflammation in the periphery. This antibody is conjugated to bd horizon pe-cf594, which has been developed exclusively by bd biosciences as a better alternative to pe-texas red™. Pe-cf594 excites and emits at similar wavelengths to pe-texas red™ yet exhibits improved brightness and spectral characteristics. Due to pe having maximal absorption peaks at 496nm and 564nm, pe-cf594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as pe-texas red™ (eg 610/20-nm filter).