Cd3 Mouse Anti-Human, Apc-R700, Clone: Ucht1, Bd, Mouse Monoclonal Antibody, Each

Details:

The ucht1 monoclonal antibody specifically binds to the human cd3 ε -chain, a 20-kda subunit of the cd3/t cell antigen receptor complex. Cd3 ε is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes. Studies from the hlda workshop show that this antibody is mitogenic for cd3 ε -positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-cd28 antibody. Cd3 plays a central role in signal transduction during antigen recognition. The ucht1 antibody stains both surface and intracellular cd3 ε unlike the other cd3 clone, hit3a, that stains only extracellular cd3 ε . This antibody was conjugated to bd horizon apc-r700, which has been developed exclusively by bd biosciences as a better alternative to alexa fluor™ 700. Apc-r700 excites and emits at similar wavelengths to alexa fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as alexa fluor™ (eg, 730/45-nm filter).