Cd3 Mouse Anti-Human, Buv395, Clone: Ucht1, Bd, Mouse Monoclonal Antibody, Each

Details:

The ucht1 monoclonal antibody specifically binds to the human cd3 ε -chain, a 20-kda subunit of the cd3/t cell antigen receptor complex. Cd3 ε is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes. Studies from the hlda workshop show that this antibody is mitogenic for cd3 ε -positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-cd28 antibody. Cd3 plays a central role in signal transduction during antigen recognition. The ucht1 antibody stains both surface and intracellular cd3 ε unlike the other cd3 clone, hit3a, that stains only extracellular cd3 ε . The antibody was conjugated to bd horizon™ buv395 which has been exclusively developed by bd biosciences as an optimal dye for use on a 355nm laser equipped instrument. With an ex max at 348nm and an em max at 395nm, this dye has virtually no spillover into any other detector. Bd horizon™ buv395 can be excited with a 355nm laser and detected with a 379/28 filter.