Cd3 Mouse Anti-Rat, Unlabeled, Clone: G4.18, Bd, Mouse Monoclonal Antibody, Each

Details:

The g4.18 Antibody reacts with the t-cell receptor-associated cd3 cell-surface antigen found on thymocytes, peripheral t lymphocytes, and dendritic epidermal t cells. It has been reported that cd3 expression is down-regulated within 24 hours in concanavalin a-stimulated rat t cells, and soluble mab inhibits the allogeneic mixed-lymphocyte proliferative response and cell-mediated cytotoxicity to allogeneic target cells. In vivo treatment with g4.18 Mab prevents cardiac and skin allograft rejection, resulting in donor-specific tolerance. Pre-incubation of splenocytes with the alternate anti-rat cd3 monoclonal antibody, 1f4 blocks staining with mab g4.18.