Cd357 (Gitr) Rat Anti-Mouse, Alexa Fluor 647, Clone: Dta-1, Bd, Rat Monoclonal Antibody, Each

Details:

The dta-1 monoclonal antibody specifically binds to gitr [glucocorticoid-induced tumor necrosis factor (tnf) receptor family-related], a 66-70-kda homodimer glycoprotein that is a member of the tnf receptor superfamily and is also known as tnfrsf18 and cd357. As its name implies, gitr expression was first detected in t lymphocytes that had been treated with dexamethasone, a glucocorticoid. In normal naive mice, gitr is expressed at moderate levels on cd25-positive/cd4-positive/cd8a-negative thymocytes and on cd25-positive/cd4-positive/cd45rb-low splenocytes. It is also expressed at low levels on splenic cd25-negative/cd4-positive/cd45rb-low t lymphocytes, b lymphocytes, macrophages, and dendritic cells. Activation of t and b lymphocytes upregulates gitr expression. Gitr is a costimulatory receptor that plays an important role in regulatory t (treg)-cell functions, and a gitr ligand has been detected on b lymphocytes, macrophages, and dendritic cells. Mab dta-1 abrogates suppression by treg cells without affecting their proliferative response, while it is co-stimulatory for t lymphocytes that are not treg cells.